Twinning_TrePsy

🎬 TrePsy – European consortium delivers new systems-oriented insights in neuropsychopharmacology

The project – Towards new treatments of psychiatric disorders: a systems-oriented approach has successfully completed its three-year research and training mission.

Funded by the European Union’s Horizon Europe programme as a Widening Twinning initiative, TrePsy brought together the expertise of the Maj Institute of Pharmacology, Polish Academy of Sciences and leading European research institutions:

🇫🇷 Neurocentre Magendie INSERM
🇩🇪 Zentralinstitut für Seelische Gesundheit
🇪🇸 UMH Universidad Miguel Hernándezez

🧠 The project focused on advancing a systems-oriented approach to neuropsychopharmacology and decoding the complex mechanisms of Cannabidiol / CBD.

TrePsy combined cutting-edge research methods with advanced training activities, including:

🔬 state-of-the-art multiomics technologies,
🧩 advanced in vivo imaging,
🧠 high-resolution brain maps,
📚 multiple peer-reviewed publications,
🎓 training opportunities for early-career researchers and young scientists.

Beyond the laboratory, TrePsy made a strong contribution to scientific capacity-building by hosting six advanced scientific schools and launching a University Specialist programme focused on cannabinoid derivatives.

As highlighted by Jan Rodriguez Parkitna from the project coordination team:

“This collaboration has not only raised the research excellence of IP PAS but has also fostered a robust network of early-career scientists equipped with the latest systems-biology tools.”

📌 The results of TrePsy provide an important scientific foundation for further research and informed policy-making on the therapeutic use of cannabinoids.

🎥 A final project movie summarising these milestones is now available online.

👉 Watch the materials and follow the project results:
▶️ TrePsy YouTube channel: https://www.youtube.com/
▶️ IF PAN YouTube channel: https://youtube.com/-yk1nh?si=ndZpqAMZyvs4XIpl
🌐 Project website: https://twinning-trepsy.eu/

🎥❄️ Although several months have passed since the 2026 Winter School, today we are revisiting this special event with the release of a report summarizing the final TrePsy School.
The film is also an opportunity to reflect on three years of collaboration within the TrePsy consortium, a Horizon Europe Twinning project bringing together leading researchers and institutions from across Europe.

In the video, participants, lecturers, and project partners share their perspectives on the project's key achievements and the future of research in neuropsychopharmacology.

Over the course of the TrePsy project, we:
🔹 organized six international scientific schools,
🔹 advanced a systems-oriented approach to studying the mechanisms of Cannabidiol (CBD),
🔹 applied cutting-edge multiomics technologies and advanced in vivo imaging methods,
🔹 launched a University Specialist programme focused on cannabinoid derivatives,
🔹 made more than 20 online lectures available to the scientific and educational community,
🔹 strengthened collaboration between the Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk and partner institutions in France, Germany, and Spain.

One of the themes that emerged during the project's final activities was the growing role of Artificial Intelligence in neuropsychopharmacology and its potential to shape the future of biomedical research.

🎬 https://youtu.be/-kRZjzbheX0

We invite you to watch the report and join us in looking back on this remarkable scientific journey.

Zentralinstitut für Seelische Gesundheit
UMH Universidad Miguel Hernández
Neurocentre Magendie
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

📸 Looking back at the TrePsy 2026 Winter School 🖤🖤

▪️The Twinning TrePsy 2026 Winter School in Kraków marked the final training milestone of the TrePsy project and brought together researchers and young scientists to discuss two rapidly developing areas: the therapeutic potential of cannabinoids and the growing role of artificial intelligence in systems neuropsychopharmacology.

▪️As we share these memories, we also remember with deep sadness Professor Jorge Manzanares Robles. His last visit to our Institute will remain in our memory as an inspiring meeting with an exceptional scientist and a remarkable person.

Zentralinstitut für Seelische Gesundheit
UMH Universidad Miguel Hernández
Neurocentre Magendie
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Prof. Jorge Manzanares Robles 🖤
With deep sadness, we received the news of the passing of Professor Jorge Manzanares Robles, an outstanding pharmacologist who gained worldwide recognition for his research in the field of neuropsychopharmacology.

▪️Professor Manzanares graduated in pharmacy from the Complutense University of Madrid in 1985 and obtained his PhD in pharmacology in 1987. In the early stages of his career, he conducted research at Ramón y Cajal Hospital and La Paz Hospital in Madrid, and from 1988 to 1993 he worked as a Research Associate at Michigan State University (USA). After returning to Spain, he continued his scientific activity at leading research institutions, including the Complutense University of Madrid, the Ramón y Cajal Institute of Neurobiology (CSIC), and Hospital 12 de Octubre. In 2004, he became Professor of Pharmacology at Miguel Hernández University in Alicante (UMH), where he also served as Dean of the Faculty of Pharmacy and headed the Laboratory of Translational Neuropsychopharmacology at the Institute of Neuroscience in Alicante (Instituto de Neurociencias CSIC - UMH). Professor Manzanares was a highly respected member of the international scientific community.

▪️He authored more than 200 scientific publications (H-index 48, over 6,700 citations), led more than 50 research projects, and delivered over 300 invited lectures worldwide. His research made important contributions to understanding the etiology and treatment of neuropsychiatric disorders.

▪️For our academic community, the opportunity to collaborate with Professor Manzanares was a great privilege. His last visit to our Institute during the Winter School Twinning TREPSY 2026 (12-13 February 2026), entitled “Therapeutic Potential of Cannabidiol in Neuropsychopharmacology,” will remain in our memory as an inspiring meeting with an outstanding scientist.

▪️Professor will remain in our memory as an outstanding scientist and mentor whose scientific achievements significantly contributed to the advancement of neuropsychopharmacology.
We extend our heartfelt condolences to his family, friends, and colleagues.

UMH Universidad Miguel Hernández
Zentralinstitut für Seelische Gesundheit
Neurocentre Magendie

❄️ Second and Final Day of the TrePsy Winter School 2026 –

With great pride and genuine emotion, we have concluded the Twinning TrePsy 2026 Winter School, held on 12–13 February 2026 in Kraków.

This was the final Winter School organized within the Twinning TrePsy 2026 Project, a unique collaboration of four leading European brain research centres advancing innovative therapeutic strategies for mental disorders:

🇵🇱 Maj Institute of Pharmacology, Polish Academy of Sciences (Kraków, Poland)
🇪🇸 Miguel Hernández University (Alicante, Spain)
🇩🇪 Central Institute of Mental Health (Mannheim, Germany)
🇫🇷 Neurocentre Magendie (Bordeaux, France)

The event brought together 75 participants — researchers, PhD students, and experts from diverse scientific backgrounds — creating a vibrant and truly international academic community.

The second day was exceptionally dynamic and intellectually energizing. We explored the role of artificial intelligence in biomedical and neuropsychopharmacological research, addressing both its transformative potential and the responsibility that accompanies its implementation.

🎓 Lectures were delivered by:

Michał Marczyk, PhD – Introduction to AI based on neural networks
Łukasz Wróbel, PhD – An Introduction to Large Language Models
Prof. Roman Z. Morawski – Ethical aspects of AI-driven technoscientific research
Sylwia Grubarek – AI in Research: From Data Processing to Discovery and Publication
Bohdan Widła, PhD – Using AI in research from the perspective of intellectual property

🔬 Key themes included:
neural networks in biomedical data analysis,
integration of large language models into scientific workflows,
AI-supported hypothesis generation and publication processes,
ethical considerations in AI-driven research,
intellectual property challenges related to generative technologies.

The speakers demonstrated that AI is no longer a distant prospect — it is actively reshaping the research landscape. At the same time, the importance of responsible, transparent, and ethically grounded AI use in mental health research was strongly emphasized.

💬 The discussions were lively, thoughtful, and deeply inspiring. Your engagement highlighted the growing importance of interdisciplinary collaboration bridging neurobiology, pharmacology, and data science.

🌍 Thank You!

We sincerely thank all 75 participants for:
your enthusiasm and engagement,
the high scientific standard of discussions,
your contribution to a truly collaborative atmosphere.

Despite the winter season, we successfully warmed up Kraków with Spanish temperament and Polish hospitality and cuisine ❄️🔥

This final Winter School within the TrePsy project was more than a scientific event — it was a space for exchange, inspiration, and lasting international connections.

We look forward to future collaborations and continued scientific dialogue.

Instituto de Neurociencias CSIC - UMH
UMH Universidad Miguel Hernández
Neurocentre Magendie
Zentralinstitut für Seelische Gesundheitlische Gesundheit
COST - European Cooperation in Science and Technology


More info: https://twinning-trepsy.eu/

With great enthusiasm and academic pride, we officially launch Winter School 2026, welcoming 70 participants – students, PhD candidates, and researchers prepared for an intensive exploration of contemporary neuropharmacology.

This event provides a platform where basic research converges with clinical translation, reflecting current trends in translational medicine and evidence-based neuroscience.

We are deeply honored to welcome our distinguished colleagues from Miguel Hernández University (UMH), Alicante, Spain:
Prof. Jorge Manzanares Robles,
Prof. María Salud García-Gutiérrez,
Prof. Francisco Navarrete Rueda,
Prof. Daniela Navarro,

as well as 20 students and doctoral researchers from Spain, whose presence strengthens the international and interdisciplinary dimension of translational neuroscience research 🌍

🧠 Day 1 Focus – Neurobiology and Clinical Implications of CBD

Today’s lectures address the neurobiological mechanisms of cannabidiol (CBD) and its therapeutic potential in neuropsychiatric and neurodegenerative disorders:

What is cannabidiol? – molecular and pharmacological foundations
Therapeutic usefulness of CBD in anxiety – modulation of anxiety-related circuits
Use of CBD in depressive disorders – potential antidepressant mechanisms
CBD in regulating behavioral and brain alterations in PTSD – stress-axis and neuroadaptive processes
CBD regulation of schizopsychotic disorders – dopaminergic and glutamatergic modulation
What is the role of CBD in the treatment of drug dependence? – translational perspectives
Is CBD useful to treat alcohol use disorder? – clinical implications
Repairing behavioral and brain alterations in a model of fetal alcohol syndrome – translational FASD models
CBD regulation of behavioral and neurochemical changes during abstinence (cannabis, co***ne, alcohol, he**in)
May CBD regulate the actions of benzodiazepines? – pharmacodynamic interactions
Therapeutic approved uses of CBD in MS and epilepsy – established clinical indications
Is CBD potentially useful in Parkinson Disease? – neuroprotective perspectives
Emerging CBD applications in Alzheimer Disease – innovative research directions

This is a day where mechanistic neuroscience informs clinical strategy, and rigorous inquiry shapes future therapeutic innovation.

📡 We will be sharing key insights from the lectures.
For now — warm up your minds and engage with scientific curiosity.

The scientific journey begins today 🚀

UMH Universidad Miguel Hernández
Instituto de Neurociencias CSIC - UMH
Neurocentre Magendie
Zentralinstitut für Seelische Gesundheit
COST - European Cooperation in Science and Technology


More info: https://twinning-trepsy.eu/

❄️ Twinning_TrePsy Winter School 2026 | 12–13 February 2026

This is the final post before the start of the TrePsy Winter School 2026 — we begin tomorrow! 🔥
We are eagerly looking forward to welcoming our lecturers and participants. Although this is the last school within the project, it promises to be exceptionally energetic, inspiring, and highly interdisciplinary.

Let’s warm up our minds — the scientific atmosphere is guaranteed! 🧠✨

We are pleased to introduce our next speakers:
Ms. Eng. Sylwia Grubarek and Dr. Bohdan Widła.

🧑‍⚕️Ms. Eng. Sylwia Grubarek – graduate of Biomedical Engineering and a fifth-year Pharmacy student.

She currently works as a pharmaceutical consultant in a research team analyzing the relationship between the human genotype and the efficacy and safety of medicinal substances.

Her interests focus on personalized medicine, pharmacogenomics, and innovative approaches supporting individualized therapy. 🌿🧬

👨‍⚕️Dr. Bohdan Widła – PhD in Law, Assistant Professor at the Chair of Intellectual Property Law, Faculty of Law and Administration, Jagiellonian University, member of the Critical Heritage Studies Hub. Until 2023, he worked as an attorney specializing in new technologies law.

🎓 Lecture:
The Use of Artificial Intelligence in Scientific Research from the Perspective of Intellectual Property Law

AI in science is a rapidly growing trend — but it also introduces new areas of risk. The lecture will address key intellectual property issues and the practical implications of using (generative) AI in the European legal context.

📌 Three practical scenarios to be analyzed:
1️⃣ Training / fine-tuning AI models for research purposes — what should researchers be aware of?
2️⃣ AI-assisted literature reviews — what are the copyright risks?
3️⃣ Writing scientific articles with generative AI — what must be considered to remain compliant with regulations?

✅ Free participation
📝 Registration: https://forms.gle/n3pdKZnEEcbyJ51U7

📍 Venue: Maj Institute of Pharmacology, Polish Academy of Sciences (IF PAN)
📚 Lectures and seminars will take place at the Institute’s headquarters
🌐 More information: https://twinning-trepsy.eu/

See you tomorrow! ❄️🚀

UMH Universidad Miguel Hernández
Instituto de Neurociencias CSIC - UMH
Neurocentre Magendie
Zentralinstitut für Seelische Gesundheit
COST - European Cooperation in Science and Technology


More info: https://twinning-trepsy.eu/

❄️Twinning_TrePsy Winter School 2026 | 12-13 12 February 2026

We are pleased to introduce our plenary speakers: Prof. Roman Z. Morawski and Prof. Jan Rodriguez Parkitna.

✅ Free participation
📝 Register here: https://forms.gle/n3pdKZnEEcbyJ51U7
📍 Venue: The Jerzy Maj Institute of Pharmacology, Polish Academy of Sciences (IF PAN)
📚 Lectures and seminars will take place at the Institute
______________________________________________________________

👨‍🔬Prof. Roman Z. Morawski is a distinguished expert in software-related aspects of measurement and measurement data processing, with broader interests encompassing the methodological and ethical dimensions of technoscientific research. He has authored or co-authored approximately 260 scientific publications in this field and is a co-inventor of 14 international patents, registered in the United States, Canada, and six European Union countries. He has delivered academic courses and lectures in metrology, measurement data processing, as well as in the methodological and ethical aspects of scientific research. In addition, he has published around 100 works addressing higher education, university governance, research methodology, and research ethics. The second edition of his textbook “Methodological and Ethical Aspects of Technoscientific Research” was published in 2024. Prof. Morawski has been affiliated with the Warsaw University of Technology as an academic staff member since 1972 and has held the position of full professor since 1993. He has spent more than ten years of his academic career at academic and industrial institutions across the European Union, the United Kingdom, and Canada. His scientific achievements have been recognized through inclusion in the annually published World’s Top 2% Scientists lists compiled by Stanford University in collaboration with Elsevier.

👨‍🔬Prof. Jan Rodriguez Parkitna is Head of the Department of Molecular Neuropharmacology at the Maj Institute of Pharmacology, Polish Academy of Sciences in Kraków; from 2021 to 2025 he served as the Institute’s Scientific Director. His research focuses on the neurobiology of reward, with particular emphasis on the role of the endogenous opioid system in reward processing, reinforcement, and social behavior. His work employs genetically modified animal models and gene expression analyses to uncover molecular mechanisms underlying both therapeutic and adverse effects of psychotropic drugs. He is the Principal Investigator of the Twinning TREPSY project – “Towards New Treatments of Psychiatric Disorders – a Systems-Oriented Approach”, which aims to develop novel therapeutic strategies for psychiatric disorders through a systems-oriented and interdisciplinary research framework. The TREPSY project is funded by the European Union’s Horizon Europe research and innovation programme (grant agreement No 10107925). In parallel, he explores the emerging role of artificial intelligence in neuropsychopharmacology.

________________________________________
UMH Universidad Miguel Hernández
Instituto de Neurociencias CSIC - UMH
Neurocentre Magendie
Zentralinstitut für Seelische Gesundheit
Fundusze Europejskie
COST - European Cooperation in Science and Technology
Politechnika Warszawska


More info: https://twinning-trepsy.eu/

❄️Twinning_TrePsy Winter School 2026 | 12-13 12 February 2026

We are pleased to introduce our plenary speakers: Łukasz Wróbel, PhD and Michał Marczyk, PhD

✅ Free participation
📝 Register here: https://forms.gle/n3pdKZnEEcbyJ51U7
📍 Venue: The Jerzy Maj Institute of Pharmacology, Polish Academy of Sciences (IF PAN)
📚 Lectures and seminars will take place at the Institute
________________________________________
Łukasz Wróbel has expertise in data analysis, machine learning, and artificial intelligence from z Silesian University of Technology, Gliwice, Poland. His research interests focus on artificial intelligence methods, with particular emphasis on interpretable machine learning models and explainable artificial intelligence. He is the author or co-author of more than 50 scientific publications in the areas of data mining, artificial intelligence, and decision support systems. He has participated in numerous research and development projects involving machine learning and artificial intelligence.

Michał Marczyk received PhD and DSc degrees in the biomedical engineering discipline from the Silesian University of Technology. He is currently an Assistant Professor with the Silesian University of Technology, an Adjunct Assistant Professor with Yale University, and a specialist in statistical data analysis, machine learning, and deep learning with strong applications in biomedicine. He proposed many data processing and analysis tools, including elements of mathematical modeling and statistics, to accurately interpret biological results and constructed several biological models of various diseases. He is a co-author of over 60 impact factor journal papers and 30 book chapters. He was involved in more than 20 scientific projects in the fields of molecular biology and bioinformatics
_____________________________________
UMH Universidad Miguel Hernández
Instituto de Neurociencias CSIC - UMH
Neurocentre Magendie
Zentralinstitut für Seelische Gesundheit
COST - European Cooperation in Science and Technology


More info: https://twinning-trepsy.eu/