Autophagy has become one of the biggest buzzwords in health.
And while itâs an incredible process...
More isnât always better.
Autophagy is your bodyâs way of recycling damaged or dysfunctional cellular components. Itâs an essential part of staying healthy.
But hereâs what most people donât realize...
Autophagy is a response to stress.
Exercise can trigger it.
Fasting can trigger it.
But so can...
Poor sleep.
Heavy metal exposure.
Air pollution.
Toxin exposure.
Even certain types of chronic physiological stress.
So simply asking, âDoes this increase autophagy?â is the wrong question.
A better question is:
Why is my body activating it in the first place?
Healthy stressorsâlike resistance training, movement, quality nutrition, and appropriate periods of fasting for the right personâcan support normal cellular renewal.
But if your body is constantly under stress from poor recovery, nutrient deficiencies, chronic inflammation, or metabolic dysfunction, increasing autophagy isnât necessarily a sign that everything is working better.
Your body isnât trying to become healthier.
Itâs trying to adapt.
Thatâs an important distinction.
The goal isnât to chase every biohacking buzzword.
The goal is to create an environment where your body can repair, recover, and produce energy efficiently.
Thatâs why I spend less time asking, âWhatâs the latest longevity hack?â and more time asking:
Are your mitochondria producing energy efficiently?
Are you recovering well?
Are you sleeping enough?
Are your hormones and metabolism being supported?
Because longevity isnât built on one pathway.
Itâs built on a healthy, resilient metabolism.
Thanks to Biohack-It and Iman Hasan for having me on the podcast!
We covered metabolism, biohacking, recovery, nutrition, and why context matters more than trends.
đ§ Catch the full episode now wherever you get your podcasts.
Zane Griggs
For high performers who feel off
Data-driven metabolic correction
Stop guessing. Get clarity.
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www.zanegriggs.com
Following my passion for health and fitness, I became a certified personal trainer in 1998.... and that's when the education really began. Working with many, different people, I found that the textbook nutritional guidelines were really not effective for many of my clients to achieve a healthy weight. This was especially true if the person were obese or had another metabolic issue. As I began look
For years weâve been told that sugar is the cause of metabolic disease.
But what if weâve been asking the wrong question?
Iâm not telling you to eat more processed sugar.
Iâm saying that blaming a single nutrient has oversimplified a much bigger problem.
A donut, for example, isnât just sugar.
Itâs refined carbohydrates, highly processed fats, low-quality ingredients, poor nutrient density, and a lot of calories packaged in a way that encourages overeating.
So why do we point the finger at one ingredient while ignoring everything else?
Hereâs something else worth thinking about...
There are several dietary interventions that are extremely high in carbohydratesâprimarily from whole foodsâthat have been shown to improve insulin sensitivity and even reverse type 2 diabetes in many people.
If carbohydrates alone caused metabolic disease, how would that be possible?
Thatâs the question that made me rethink everything.
The real conversation isnât:
âAre carbs good or bad?â
Itâs:
Why has your body lost the ability to use them efficiently?
Thatâs where metabolic health begins.
Instead of fearing carbohydrates, I want to understand whatâs happening underneath the surface.
Are your mitochondria producing energy efficiently?
Are you metabolically flexible?
Are stress hormones elevated?
Howâs your sleep?
Howâs your thyroid?
Howâs your gut?
Those are the questions that actually move the needle.
When you stop chasing villains and start understanding physiology, nutrition becomes a lot less confusing.
Big thanks to Mark Bell for having me on the Mark Bellâs Power Project Podcast. We had an incredible conversation challenging some of the biggest assumptions in nutrition and metabolic health. Mark Bell Mark Bellâs Power Project
đď¸ Listen to the full episode now wherever you get your podcasts.
What if metabolic disease isnât simply your genetic destiny?
Your genes may influence risk, but lifestyle, nutrition, movement, sleep, and metabolic health can play a powerful role in what happens next. Instead of assuming diabetes, insulin resistance, or other metabolic conditions are inevitable, understanding the factors you can influence may completely change how you approach your long-term health.
08/18/2026
Just because a diet helped someone lose weight in the short term doesnât mean itâs supporting long-term hormonal health.
This is one of the biggest mistakes I see in the health and fitness world.
A lot of people assume that if the scale is going down, everything must be improving. But weight loss alone doesnât tell you whatâs happening to your metabolism, thyroid, or hormones.
Iâve worked with countless women (and men) who thought carbohydrates were the enemy. They were eating plenty of protein, avoiding fruit, cutting carbs as low as possible, and wondering why they still felt exhausted.
Their complaints were almost always the same:
⢠Low energy
⢠Cold hands and feet
⢠Brain fog
⢠Hair loss
⢠Poor recovery
⢠Stubborn fat loss despite doing âeverything rightâ
More protein wasnât the missing piece.
For many of them, chronic carb restriction had become another metabolic stressor.
Your thyroid doesnât just need proteinâit also needs enough energy to function optimally. When metabolism slows down, your body adapts by conserving energy. Thatâs great for surviving a famine, but not so great if your goal is to feel strong, lean, energized, and healthy.
The problem is when people assume that one strategy is the best strategy for everyone, forever.
In my practice, when we strategically reintroduce the right carbohydratesâthings like fruit, fruit juice, and other easy-to-digest whole-food carbohydrate sourcesâmany people notice improvements in energy, recovery, blood sugar, body temperature, digestion, and, ironically, fat loss.
The goal isnât to fear carbohydrates.
The goal is a healthy, flexible metabolism that can efficiently use both carbohydrates and fat for fuel.
If youâre dealing with stubborn weight, fatigue, cold hands and feet, brain fog, or poor recovery, your thyroid and metabolism deserve a closer look.
Or if youâre ready to stop guessing and want to understand whatâs actually happening inside your body, comment âLABSâ and Iâll help you order the right labs and build a custom metabolic plan based on your results.
08/16/2026
If youâve followed me for a while, you probably remember when I was one of the biggest advocates for intermittent fasting.
I talked about it on podcasts.
I recommended it to clients.
I was even writing a book about it.
And for a long time...
It worked.
Until it didnât.
Somewhere in my early 50s, I hit a wall.
My sleep started getting worse.
I wasnât recovering from workouts like I used to.
I felt run down all the time.
My fasting blood sugar started creeping up, and my thyroid looked ânormalâ on paperâbut it certainly wasnât optimal.
At the time, I was doing a 24-hour fast every week, fasting 15â18 hours most days, and often finishing those fasts with a strength workout before I finally ate.
Looking back, I realized I wasnât just fasting.
I was piling stress on top of stress.
I remember talking with my friend and sleep coach, Mollie Eastman, about everything I was experiencing.
She said something Iâll never forget:
âIt works... until it doesnât.â
That was the moment everything changed.
I stopped fasting.
Then I slowly started increasing my carbohydrates.
First to around 250â300 grams a day.
Eventually to 350â400+ grams a day while lowering my fat intake.
I was concerned my blood sugar might get worse.
InsteadâŚ
My blood sugar came down.
My A1C improved.
My sleep improved.
My recovery improved.
I felt like myself again.
Thatâs when I realized I hadnât created a carbohydrate problem.
I had created a metabolic stress problem.
I had spent years over-relying on stress hormones like cortisol and glucagon to keep me going, and eventually my body let me know it wasnât sustainable anymore.
The biggest lesson?
Just because something works now doesnât mean it will work forever.
Your metabolism changes.
Your body changes.
And sometimes the healthiest thing you can do is have the humility to change your mind when your own physiology tells you itâs time.
What worked, or at least what I thought was working, for me at 40 wasnât what my body needed at 52.
Thatâs why I always say:
Test. Donât guess.
Your body will tell you what it needsâif youâre willing to listen.
08/13/2026
đĽ Over 50 doesnât mean operating at 50%.
Stop settling for less energy, less strength, and less of the life you want to live.
â¨Itâs time to have a real conversation about menâs health after 50.
đ¤PANEL - Mens Health Over 50 - with these superstars:
Dr. Sean OâMara
Zane Griggs
Brad Kearns
Jean Titus
John Garvey
â¨Your questions. Our experts. Real talk about menâs healthâfrom science to real-world experience.
Five panelists. Different perspectives. One live conversation about what men can do now to optimize their health, performance, and longevity for the decades ahead.
Bring your questions. This is one youâll want to be in the room for.
đď¸ Get your ticket and join us in Tampa.â¨đ hackyourhealth.comâ¨đŤ Use code HYH2026 to save $100â¨đ
November 13â15, 2026 | Tampa, FL
08/11/2026
GLP-1s are being massively overused, overdosed, and misunderstood.
The conversation has become so polarized.
Some people think theyâre a miracle.
Others think theyâre poison.
I think both sides are asking the wrong question.
The real problem isnât just the medication.
Itâs how itâs being used.
One of the biggest mistakes I see is people taking doses so high that they completely lose their appetite.
They stop eating enough.
They stop prioritizing protein.
They stop strength training.
Instead of reducing food noise, theyâre essentially starving themselves into weight loss.
Yes, the scale moves.
But so does muscle.
So does metabolic rate.
Weight loss should never come at the expense of your metabolism.
Thereâs a huge difference between quieting food noise and eliminating your appetite altogether.
When people stop eating enough, theyâre often not just underfedâtheyâre undernourished.
Protein intake drops.
Muscle becomes harder to maintain.
Strength declines.
Recovery suffers.
And when muscle goes, metabolism usually follows.
Then comes the question I hear almost every week...
âHow do I get off?â
Because eventually hunger returns.
If the medication was doing all the work, the weight often comes back too.
Thatâs why this conversation has to become about more than weight loss.
It has to become about metabolism.
About preserving muscle.
About supporting your body instead of simply eating less.
The goal shouldnât be to lose weight as fast as possible.
The goal should be building a metabolism that can keep the weight off long after the medication is gone.
Weâre going to continue unpacking this because there is a lot of misinformation surrounding GLP-1s, and people deserve to understand whatâs actually happening inside their bodiesânot just what the scale says.
Comment GUIDE if youâd like my free Metabolic Stress Marker Guide, or comment LABS if youâre ready to stop guessing and find out whatâs really driving your metabolism.
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